Bonn [Germany], February 24 (ANI): Spatial navigation and memory are essential aspects of our daily lives. Without these abilities, we would struggle to navigate our surroundings and recall past experiences. However, the neural basis of spatial memory is poorly understood.
A study group led by Prof. Lukas Kunz, who recently joined the University Hospital Bonn (UKB), discovered new information about this knowledge gap. He discovered, with scientists from New York and Freiburg, that different types of nerve cells activate simultaneously during spatial memory and are coordinated by brain waves (“ripples”). The results have been published in the journal Nature Neuroscience.
Associative memory allows different pieces of information are linked together.
“In the context of spatial memory, associative memory enables us to remember the locations of certain objects in the spatial environment,” explains Prof. Kunz, research group leader for Cognitive and Translational Neuroscience at the Department of Epileptology at the UKB. He is also a member of the Transdisciplinary Research Area (TRA) “Life & Health” at the University of Bonn. “For example, we can remember where in the house we put our keys”. At older age or in certain diseases such as Alzheimer’s, however, this ability is limited. “It is therefore important to investigate the neuronal basis of different forms of human memory,” said Prof. Kunz. In the long term, this could help develop new therapies for memory impairments.
Nerve cells are active while information is retrieved from memory. To further investigate this phenomenon, the researchers recorded the activity of individual nerve cells in epilepsy patients performing a memory task. “In a virtual world, the participants were asked to remember the locations of different objects,” explains Prof. Kunz.
The recordings showed that different types of nerve cells became active during this memory task. Some nerve cells responded to certain objects, while other nerve cells activated in response to certain locations. The scientists observed that interactions between the different types of nerve cells became stronger over time when participants remembered the right object in the right place.
In addition to place and object neurons, the researchers observed hippocampal brain waves (“ripples”) that also occurred during the memory task, presumably playing a crucial role in the formation and retrieval of associative memories. “Ripples could be important for the connection of different types of nerve cells and the formation of complex memories. It will be exciting to further investigate this idea in future studies,” explains Prof. Kunz.
It will also be interesting to study how memory performance is modulated when ripples are suppressed or triggered, providing insights into the causal relevance of ripples.
Prof Kunz intends to continue the findings that he gained with his colleagues at Columbia University’s School of Engineering and Applied Science in New York and the University of Freiburg at the University Hospital Bonn.
“The department of epileptology at the UKB is well-known for its excellent brain research. The department has the unique opportunity to record the activity of individual nerve cells in the human brain in the video EEG monitoring unit, which is the heart of every epilepsy center. This provides exciting insights into the functioning of the human brain, which is only possible at a few research centers worldwide,” describes Prof. Kunz.
In his interdisciplinary research, he builds on the close exchange with other researchers and medical doctors, which is essential for the development of new research ideas. (ANI)
